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New Children's Dinosaur books by Weiming Xu The Trilogy of the Adventures of a Little Dinosaur Diwills New Title:Author Weiming Xu A Football Fan's Sketch Diary from May 2022 to July 2024 I live in the north London Tottenham area. So naturally I am excited fan of the Tottenham Spurs football CLUB,OR they callefSpursey fans.Since May 2022,Antonio Conte,our head coach has led our football team to the top4. Wevwrtr very excited as we were going to play in the European Champions League. So I embarked on a sketch from that time until the season finished. This book was about the events as well as other events during that time. ISBN:9781739428921 New Title: Author Weiming Xu 7 The Trilogy of The Adventures of a Little Dinosure Dinowills. This book is the trilogy on a little dinosaur dinowills, who was a strange creature, made of half dinosaur and half whale, who survived 66 million years hibernation after big bang of the asteroid hitting the Earth. Waken up in the water by global warming. She immediately done heroics work by saving the Gigantic Pisa Tower from falling(Volume 1). She then blows a magic puff to kill the coronavirus (Volume II). She then rescues the Koalas in the forest fire by using magic spell to waken the Three Sisters in the Blue Mountains in Australia(Volume III). There are a lot of things happening there! ISBN:9781739428907 New Title: The Adventures of a Little Dinosure Dinowills 3: Dinosaur rescues Koalas from the forset fire. This book is last part of trilogy on a little dinosaur dinowills, which is created by the author three years ago, when a strange dinosaur, made of half dinosaur and half whale survived 66 millons year in hibernation. Waken up in shallow water by global warming. She immediately done heroics work by saving the Gigantic Pisa Lening Tower(the first book, The adventures of a little dinosaur dinowills, Dinosaur rescues leaning Pisa tower, 2019). She then blows a magic puff to kill the coronovirus(2nd book in the series,published in 2020). This is the third book of the serious about dinosaur rescues the koalas in the forest fire, by using magic Spell to awakening the three sisters in the Blue Mountains in Australia. There are a lot of A lot of interesting things happening there! ISBN:9798354458028 New title: The Adventures of a little Dinosaur Dinowills: Dinosaur rescues the Pisa Leaning Tower ISBN: 9781687697011 W.X.Clark New Title: The Adventures of a Little Dinosure Dinowills: Dinosaur Blows a Magic Puff to kill the Coronavirus ISBN:9798685179463 New Title by Weiming Xu New Cardiovascular Research:Pcsk9 as a new therapeutic target for Cardiobascular disease ISBN:9798533140058 New Cardiovascular Research/p> lots of links < visit Adventures of a little dinosaur dinowillsborder="0" A>border="0" Congratulations for Papa Matar Sarr scoes an open goal to depose Manchester United in 2:0 win a thrilling match as Spurs new coach Ange Postecoglou got his first home game win in the new season. Congratulations for Spurs new captain Son Haung-min scors a hat trick for 5:2 won over Bournemouth Congratulations fot King Novak won the 24 grand slam trophys in 2023 us open Congratulations for Richarlison and Kuloserski scored for spurs for 2:1 win to Sheffield united Congratulations for spurss captain Heung-min Son scored 2 goal toe to toe to Arsenal for 2:2 draw in local derby 07/10 Match between Liverpool verse Spurs has a VAR scandal when on site offical called Luis Diaz goal offside , disallowd Liverpool goal , abd VRA team gave wrong "check complete", resulting final result 2:1 Spurs win Micky van de Van scored a winning goal, 1:0 to Luton, shot Tottemham Hotspur to the Top pf League before international break 7.10.2023 Congratulations for Spurs 2:0 win over Fulham by Son and Maddison, spurs back on top of the league again!! Dejan Kuluserski scored in 90 minitesgoal to earn 3:3 draw to Manchester City, ending Tottemham Hotspur 3 consective defeats 2.12.2023 Richarlison's two goals and Son's penalty Ugogies's first goal help Spurs 4:1 to Newcastle jumped out losing stretch 5 games no win 10.12.2023 Congratulations for Ellie and Vito won Strictly! Happy New Year 2024!! Congratulations for spurss 2:1 win over brighton with Brenna Johnson scored a winning goal in 96 mins throughcaptain Heung-min Son brillian pass. at 10/02/2024 send spur back to top4 temperaly Congratulations for James Maddision scored 1st goal of 4 goals feast wih Johnson,Son and new boy Werner on the score sheet for 4:0 win for Spurs won over Stton Villa to keep top 4 hope alive! at 10/03/2024 Pedro Porro scored a fantastic goal as Spurs takes 3:1 win over Nottingham Forest, Back to top4 in last two months.07/04/2024 Pedro Porro and Van de Ven scored a fantastic goal each to celebrated 2:1 over Burnley in 11/05/2024 as Spurs suffuerd 4 consective defeats in last 4 games summer harvest:my new tomatos Congratulations for spurs 4:0 win over everton with Bissouma scored first goal and Heung-min Son 2 goals and Romero one goal 24/08/2024 Xu, W.; Liu, L.; Hornby, D. c-IAP1 Binds and Processes PCSK9 Protein: Linking the c-IAP1 in a TNF-α Pathway to PCSK9-Mediated LDLR Degradation Pathway. Molecules 2012, 17, 12086-12101. Abstract: Recent genetic studies have shown that PCSK9, one of the key genes in cholesterol metabolism, plays a critical role by controlling the level of low-density lipoprotein receptor. However, how PCSK9 mediates LDLR degradation is still unknown. By combining a shotgun proteomic method and differential analysis of natural occurring mutations of the PCSK9 gene, we found that an E3 ubiquitin ligase c-IAP1 binds and processes PCSK9 protein. One of the ‘gain-of-function’ mutations, S127R, is defective with respect to binding to c-IAP1, and thus has defective autocatalytic activity. Knockdown of c-IAP1 impairs PCSK9 processing and autocatalytic cleavage. In c-IAP1 null mouse embryonic fibroblasts (MEFs), there is a dramatic decrease in secreted mature PCSK9 protein accompanied by a significant increase in LDLR protein levels compared with matched wild-type MEF cells. c-IAP1 also acts as an E3 ligase for ubiquitination of PCSK9. Ubiquitin containing only lysine-27 mediated PCSK9 ubiquitination by c-IAP1. Given K27-linked polyubiquitination promotes lysosomal localization, the finding indicates the c-IAP1 acts on both secretion of PCSK9 and its lysosomal localization. The novel pathway described here will open new avenues for exploring novel disease treatments. Just published in
W.X.Clark
New Cardiovascular Research/p>
< visit Adventures of a little dinosaur dinowillsborder="0" A>border="0"
Congratulations for Papa Matar Sarr scoes an open goal to depose Manchester United in 2:0 win a thrilling match as Spurs new coach Ange Postecoglou got his first home game win in the new season.
Congratulations for Spurs new captain Son Haung-min scors a hat trick for 5:2 won over Bournemouth
Congratulations fot King Novak won the 24 grand slam trophys in 2023 us open
Congratulations for Richarlison and Kuloserski scored for spurs for 2:1 win to Sheffield united
Congratulations for spurss captain Heung-min Son scored 2 goal toe to toe to Arsenal for 2:2 draw in local derby
07/10 Match between Liverpool verse Spurs has a VAR scandal when on site offical called Luis Diaz goal offside , disallowd Liverpool goal , abd VRA team gave wrong "check complete", resulting final result 2:1 Spurs win
Micky van de Van scored a winning goal, 1:0 to Luton, shot Tottemham Hotspur to the Top pf League before international break 7.10.2023
Congratulations for Spurs 2:0 win over Fulham by Son and Maddison, spurs back on top of the league again!!
Dejan Kuluserski scored in 90 minitesgoal to earn 3:3 draw to Manchester City, ending Tottemham Hotspur 3 consective defeats 2.12.2023
Richarlison's two goals and Son's penalty Ugogies's first goal help Spurs 4:1 to Newcastle jumped out losing stretch 5 games no win 10.12.2023
Congratulations for Ellie and Vito won Strictly!
Happy New Year 2024!!
Congratulations for spurss 2:1 win over brighton with Brenna Johnson scored a winning goal in 96 mins throughcaptain Heung-min Son brillian pass. at 10/02/2024 send spur back to top4 temperaly
Congratulations for James Maddision scored 1st goal of 4 goals feast wih Johnson,Son and new boy Werner on the score sheet for 4:0 win for Spurs won over Stton Villa to keep top 4 hope alive! at 10/03/2024
Pedro Porro scored a fantastic goal as Spurs takes 3:1 win over Nottingham Forest, Back to top4 in last two months.07/04/2024
Pedro Porro and Van de Ven scored a fantastic goal each to celebrated 2:1 over Burnley in 11/05/2024 as Spurs suffuerd 4 consective defeats in last 4 games
summer harvest:my new tomatos
Congratulations for spurs 4:0 win over everton with Bissouma scored first goal and Heung-min Son 2 goals and Romero one goal 24/08/2024
Xu, W.; Liu, L.; Hornby, D. c-IAP1 Binds and Processes PCSK9 Protein: Linking the c-IAP1 in a TNF-α Pathway to PCSK9-Mediated LDLR Degradation Pathway. Molecules 2012, 17, 12086-12101.
Abstract: Recent genetic studies have shown that PCSK9, one of the key genes in cholesterol metabolism, plays a critical role by controlling the level of low-density lipoprotein receptor. However, how PCSK9 mediates LDLR degradation is still unknown. By combining a shotgun proteomic method and differential analysis of natural occurring mutations of the PCSK9 gene, we found that an E3 ubiquitin ligase c-IAP1 binds and processes PCSK9 protein. One of the ‘gain-of-function’ mutations, S127R, is defective with respect to binding to c-IAP1, and thus has defective autocatalytic activity. Knockdown of c-IAP1 impairs PCSK9 processing and autocatalytic cleavage. In c-IAP1 null mouse embryonic fibroblasts (MEFs), there is a dramatic decrease in secreted mature PCSK9 protein accompanied by a significant increase in LDLR protein levels compared with matched wild-type MEF cells. c-IAP1 also acts as an E3 ligase for ubiquitination of PCSK9. Ubiquitin containing only lysine-27 mediated PCSK9 ubiquitination by c-IAP1. Given K27-linked polyubiquitination promotes lysosomal localization, the finding indicates the c-IAP1 acts on both secretion of PCSK9 and its lysosomal localization. The novel pathway described here will open new avenues for exploring novel disease treatments.
Recent Research Breakthrough in NO
Linking mitochondrial signalling to ER-stress by nitric oxide
Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response.
Xu W, Liu L, Charles IG, Moncada S.
Nitric oxide (NO) is a pleiotropic signalling molecule that binds to cytochrome c oxidase (complex IV) reversibly and in competition with oxygen. This action of NO has both physiological and pathophysiological consequences. Here we report that endogenously generated NO, which disrupts the respiratory chain, may cause changes in mitochondrial calcium flux. This induces cleavage of the endoplasmic reticulum (ER) stress-regulated transcription factor p90 ATF6 into an active p50 form. Cleavage depends on a calcium-dependent serine protease through a regulated intramembrane proteolysis (RIP) process. p50 ATF6 then translocates to the nucleus to upregulate expression of the ER-resident molecular chaperone, glucose-regulated protein 78 (Grp78). The increase in Grp78 provides significant cytoprotection against toxic agents, including thapsigargin, a selective ER calcium-ATPase inhibitor. Cytoprotection is abolished after treatment with cyclosporin A (CsA), which disrupts mitochondrial calcium signalling, or with the calcium chelator BAPTA-AM. The NO-mediated ER stress response is diminished in rho(0) cells devoid of mitochondrial DNA, consistent with our evidence that NO-dependent mitochondrial disruption is coupled to the ER stress response.
Nat Cell Biol. 2004 Nov;6(11):1129-34. Epub 2004 Oct 24.
<(PDF) cited in mitochondria and NO.html
Recent Research Review NO & Cancer
Nitric oxide and COX-2 pathway;2009 Targeting Cyclooxygenase and Nitric Oxide Pathway Cross-Talk: A New Signal Transduction Pathway for Developing More Effective Anti- Inflammatory Drugs
Targeting Cyclooxygenase and Nitric Oxide Pathway Cross-Talk: A New Signal Transduction Pathway for Developing More Effective Anti- Inflammatory Drugs
Current Signal Transduction Therapy Volume 4. The Journal Site
Current Signal Transduction Therapy, Volume 4(1)Pp. 66-75
This page is devoted to the nitric oxide user and researcher . There are three different type of nitric oxide synthases: neuronal nitric oxide synthase(NOS1), inducible nitric oxide synthase(NOS2) and endothelium nitric oxide synthase(NOS3). Each of them have different tissue distributions and located on different human chromosomes. They may related to many human diseases, such as Alzheimer 's dieseases, Parkinson's. diabetes, asthma, heart disease, infection diseases.Some nitric oxide reagents, such as nitric oxide cDNAs, genomic DNAs, nitric oxide polymorphic markers, nitric oxide antibodies, Nitric oxide synthase proteins and other information will be helpful for these researchers. In my favorite site , you can find them all. This page also contain some information about human genetics, human identity, microsatellite information .
Merry Christmas and happy new year from W.X.Clark
Research ID FASEB J, 16, 213-215(2002).[Abstract] [PDF]
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Cancer Research Breakthrough Targeting Nitric Oxide Mediated Upregulation of Membrane-bound Glucose Regulated-protein 78 by Subtractive Single Chain Variable Fragment (scFv) Phage Nitric oixde website for advice in information or productsclick here to send
Targeting Nitric Oxide Mediated Upregulation of Membrane-bound Glucose Regulated-protein 78 by Subtractive Single Chain Variable Fragment (scFv) Phage